No Link Between Antihypertensive and Cancer Risk

No Link Between Antihypertensive and Cancer Risk

According to the press release from ESC (European Society of Cardiology), there is no evidence that blood pressure lowering drugs (antihypertensive as an example) increase the risk of cancer.

“Our results should reassure the public about the safety of antihypertensive drugs with respect to cancer, which is of paramount importance given their proven benefit for protecting against heart attacks and strokes,” said study author Ms. Emma Copland, an epidemiologist at the University of Oxford, UK.

The authors said that the question about a potential link between blood pressure drugs and cancer has been debated for more than 40 years. Coincidences were often the evidence for an increased or decreased risk of cancer while using antihypertensive medication, but these coincidences has been inconsistent and conflicting.

260,000 Volunteers In 31 trials

“This was the largest study on cancer outcomes in participants of randomized trials investigating antihypertensive medication – around 260,000 people in 31 trials. Investigators of all trials were asked for information on which participants developed cancer. Much of this information has not been published before, making the current analysis the most detailed yet,”- according to press release.

Study continued for four years. Scientist used five antihypertensive drug classes were investigated separately: angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), beta blockers, calcium channel blockers (CCBs), and diuretics.

Researchers looked up the effect of each drug class on the risk of developing any type of cancer, of dying from cancer, and of developing breast, colorectal, lung, prostate and skin cancers. They include differences between volunteers in age, gender, body size, smoking status and previous antihypertensive medication use before taking part in the trial. During this year were around 15,000 new diagnoses of cancer, and comparing to the total amount it’s significantly less, especially in percentage terms.

Only About 6% From Total Amount Get Cancer

Calculation of the percentage give as a result, that from total 260.000 group of people only 15.000 get cancer, with is only about 6% from total amount.

Authors said – “There was no important effect of any individual drug class on overall cancer risk. The hazard ratio (HR) for any cancer was 0.99 (95% confidence interval [CI]) 0.94–1.04) with ACE inhibitors, 0.97 (95% CI 0.93–1.02) with ARBs, 0.98 (95% CI 0.89–1.08) with beta blockers, 1.06 (95% CI 1.01–1.11) with CCBs and 1.01 (95% CI 0.95–1.07) with diuretics. In statistical terms, these effect sizes were not significantly different from each other, so there was no evidence of an increased risk of cancer with any of the drug classes.”

The research confirms that there was no evidence that any type of antihypertensive medication had an effect on the probability of developing breast, colorectal, lung, prostate or skin cancer.

Ms. Copland said: “Our study has addressed an ongoing controversy about whether antihypertensive medication increases the risk of developing cancer. We used the largest individual-level randomized evidence on antihypertensive medication to date and provide evidence for the safety of blood pressure lowering drugs in relation to cancer.”

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